Overeating leads to brain changes that feed your appetite.


The Centers for Disease Control estimates a third of American adults are obese, and another third are considered overweight. Now, a new study from the University of Washington may shed some light on why it’s so hard to lose weight.

You don’t even notice, but the more you eat, the harder it is to feel full. Scientists wanted to find out why.

“The number of people losing weight or stating that they have tried to lose weight over the past year is 50%,” said Ellen Schur, MD at UW Medicine Diabetes Institute.

Schur helps patients lose weight. She says weight loss itself causes hormone changes that make food more appealing, so it’s harder to keep weight off.

Researchers from UW Medicine Center for the Neurobiology of Addiction, Pain and Emotion found that the body adapts to excess eating.

Mark Rossi and Marcus Basiri’s study shows that overeating changes brain cells that suppress food intake.

“We don’t know the exact mechanisms that are contributing to it, but we see that there are profound changes across lots of different cell types,” Rossi said.